ExProt DB
Extremophile Protein Database
ExProt DB

   Advanced Search  

 
 

Protein Information

 

Protein Details

ExProtDB ID
A.0000H0.05.H02
Name
Dps-like ferritin
Extreme Stable Behaviour
Halostable

Source Organism

ExProtDB ID
A.0000H0.05
Name
Halobacterium salinarum
Domain
Archaea
Extremophile Type
Halophile

Protein Function

Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction (By similarity).

Protein Classification

EC ID
E1
EC Number
1.16.-.-
Type
DNA BINDING PROTEIN

Optimum Physiochemical Conditions

Extreme-Stability ID
HA03
Optimum Condition
2.5-5.2M NaCl

Protein Sequence

UniProt KB ID
Molecular Weight (Da)
20100.0
Sequence Length
(amino acid numbers)
182
Sequence
MSTQKNARATAGEVEGSDALRMDADRAEQCVDALNADLANVYVLYHQLKKHHWNVEGAEFRDLHLFLGEAAETAEEVADELAERVQALGGVPHASPETLQAEASVDVEDEDVYDIRTSLANDMAIYGDIIEATREHTELAENLGDHATAHMLREGLIELEDDAHHIEHYLEDDTLVTQGALE

Protein Parameters

PID
H.P0029
Amino acid content (%)
 
Ala
14.835
Cys
0.549
Asp
9.89
Glu
13.736
Phe
1.099
Gly
5.495
His
6.044
Ile
3.297
Lys
1.648
Leu
10.989
Met
2.198
Asn
3.297
Pro
1.099
Gln
3.297
Arg
4.396
Ser
2.747
Thr
5.495
Val
6.593
Trp
0.549
Tyr
2.747
Amino acid class contents(%)
 
Tiny (A+C+G+S+T)
29.12
Small (A+C+D+G+N+P+S+T+V)
50.00
Aliphatic (A+I+L+V)
35.71
Aromatic (F+H+W+Y)
10.44
Non Polar (A+C+F+G+I+L+M+P+V+W+Y)
49.45
Polar (D+E+H+K+N+Q+R+S)
50.55
Charged (D+E+H+K+R)
35.71
Basic (H+K+R)
12.09
Acidic (D+E)
23.63
Intraprotein interactions (%)
 
Main Chain Main Chain Hydrogen Bonds
8.83
Main Chain Side Chain Hydrogen Bonds
2.82
Side Chain Side Chain Hydrogen Bonds
3.32
Hydrophonic Interactions
2.60
Ionic Interactions
1.39
Salt Bridges
2.05
Aromatic Aromatic Interactions
0.13
Aromatic Sulphur Interactions
0.02
Cation Pi Interactions
0.15
Disulphide Bridge Interactions
0.00

Protein Structure Details

RCSB PDB ID
Structure Resolution (A)
1.9
PMID
Authors
Zeth, K., Offermann, S., Essen, L.O., Oesterhelt, D.
Journal
Proc.Natl.Acad.Sci.USA
Title
Iron-oxo clusters biomineralizing on protein surfaces: Structural analysis of Halobacterium salinarum DpsA in its low- and high-iron states.
Volume
101
Year
2004

Information Source

UniProt, RCSB PDB and BRENDA