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Extremophile Protein Database
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Protein Information

 

Protein Details

ExProtDB ID
A.0000H0.05.L01
Name
ALKALINE PHOSPHATASE
Extreme Stable Behaviour
Alkalistable

Source Organism

ExProtDB ID
A.0000H0.05
Name
Halobacterium salinarum
Domain
Archaea
Extremophile Type
Halophile

Protein Function

Not known

Protein Classification

EC ID
E3
EC Number
3.1.3.1
Type
HYDROLASE

Optimum Physiochemical Conditions

Extreme-Stability ID
PH10
Optimum Condition
pH 10.5

Protein Sequence

UniProt KB ID
Molecular Weight (Da)
49305.0
Sequence Length
(amino acid numbers)
473
Sequence
MPTPHTTESPSVDRRTFLAGLSGAVAGGAVASQFQTTARAQATASPAANAIAYIVDGMGQTQISAARYLNAYKTAPERFPLNVSPAETPTGFDAFSSRGSMTTFPDDPYETTTDSAAAATAFASGVKTYNGAIGGVQTSGGGFQRVDTVLERASAQGYATGLITTTEATHATPAAFAAHVEDRGNQTEIARQYIEETQPDVILGGQRRDFEADASNGGTLVDAARDNGYTIAETAAELDAVDDPPVLGLFSQESHLDYYLDRKNDPENTQPNLDAMVDAGVDLLSSAGDPDKGFFLLVESGRVDHAGHANYPAQVAEQYEATQVAGQLVEYAETTAEPTFLVSTGDHECGGLTLGRDSPYEVEYDVLAAQKATTSRLRDLLAGVRSADELESIVAAHTGITALTDREVAKLRDAPGSISTILAERAGIAFTTDGHTGTDVPVFAHGPNAARFDAARDNTAVADALAAALGVSL

Protein Parameters

PID
L.P0002
Amino acid content (%)
 
Ala
16.702
Cys
0.211
Asp
7.822
Glu
5.92
Phe
3.594
Gly
8.879
His
2.114
Ile
2.96
Lys
1.268
Leu
6.977
Met
0.846
Asn
2.748
Pro
4.863
Gln
4.017
Arg
5.074
Ser
5.92
Thr
10.359
Val
6.554
Trp
0
Tyr
3.171
Amino acid class contents(%)
 
Tiny (A+C+G+S+T)
42.07
Small (A+C+D+G+N+P+S+T+V)
64.06
Aliphatic (A+I+L+V)
33.19
Aromatic (F+H+W+Y)
8.88
Non Polar (A+C+F+G+I+L+M+P+V+W+Y)
54.76
Polar (D+E+H+K+N+Q+R+S)
45.24
Charged (D+E+H+K+R)
22.20
Basic (H+K+R)
8.46
Acidic (D+E)
13.74
Intraprotein interactions (%)
 
Main Chain Main Chain Hydrogen Bonds
14.29
Main Chain Side Chain Hydrogen Bonds
6.59
Side Chain Side Chain Hydrogen Bonds
2.84
Hydrophonic Interactions
5.74
Ionic Interactions
1.30
Salt Bridges
1.13
Aromatic Aromatic Interactions
0.22
Aromatic Sulphur Interactions
0.03
Cation Pi Interactions
0.16
Disulphide Bridge Interactions
0.00

Protein Structure Details

RCSB PDB ID
Structure Resolution (A)
1.7
PMID
Authors
Wende, A., Johansson, P., Vollrath, R., Dyall-Smith, M., Oesterhelt, D., Grininger, M.
Journal
J.Mol.Biol.
Title
Structural and Biochemical Characterization of a Halophilic Archaeal Alkaline Phosphatase.
Volume
400
Year
2010

Information Source

UniProt, RCSB PDB and BRENDA